Prof. Edoardo Di Naro

domenica 11 marzo 2018

https://link.springer.com/article/10.1245%2Fs10434-015-4655-4 (leggi tutto)

Daniele Bolla
Sarah In-Albon
Andrea PapadiaEmail author
Edoardo Di Naro
Maria Luisa Gasparri
Michael M. Mueller
Luigi Raio

Gynecologic Oncology

First Online: 03 June 2015

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Abstract

Purpose

The aim of this present study was to evaluate the sonographic correlation between Doppler flow characteristics of the uterine arteries and tumor size in patients with cervical cancer, in order to establish a new potential marker to monitor treatment response.

Methods

This was a retrospective cohort study of 25 patients who underwent a sonographic evaluation of Doppler flow characteristics of the uterine arteries before surgery or radiochemotherapy for early and locally advanced/advanced cervical cancer, respectively, was analyzed. The primary outcome was the correlation between Doppler flow characteristics of the uterine arteries and tumor size in patients with cervical cancer.

Results

Median age was 49 (range 26–85) years, and mean tumor size was 40.8 ± 17 mm. A significant positive correlation was found between tumor diameter and the uterine artery end-diastolic velocity (r = 0.47, p < 0.05) as well as the peak systolic velocity (r = 0.41, p < 0.05). No correlation was found between tumor size and the pulsatility index or resistance index.

Conclusions

In cervical cancer, uterine artery velocity parameters are associated with tumor size. This finding could become particularly useful in the follow-up of locally advanced cervical cancer patients undergoing radiochemotherapy or in corroborating the selection of women with more possibility of a high response rate during neoadjuvant chemotherapy before surgery.

sabato 10 marzo 2018